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Patients were evaluated at baseline and at 13612 months of follow-up with the IKDC subjective, VAS, KOOS, and EQ-VAS scores

Soluble oligomers of amyloid-beta cause changes in redox state, DNA methylation, and gene transcription by inhibiting EAAT3 mediated cysteine uptake

Results vary by individual based on age, genetics, baseline health, and treatment adherence

However, the diversity in study subjects, supplementation methods, and duration of intake has led to inconsistent findings

46 Thus, DNA damage caused by mitochondria-derived endonuclease and others contribute to cell necrosis, and attempts to repair the damage limit the injury and support recovery

However, these measures are susceptible to interpretive bias and fail to accurately capture dynamic fatigue states, which may undermine data reliability [186, 187]